Кафедра "Органічний синтез та фармацевтичні технології"

Постійне посилання колекціїhttps://repository.kpi.kharkov.ua/handle/KhPI-Press/7484

Офіційний сайт кафедри http://web.kpi.kharkov.ua/nanochem

Від січня 2022 року кафедра має назву "Органічний синтез та фармацевтичні технології", попередня назва – "Органічний синтез та нанотехнології" (НАКАЗ 31 ОД від 21.01.2022 року).

Найбільш істотну реорганізацію зазнала кафедра в 1929-1950 роках, коли відбувся поділ на ряд галузевих інститутів, і в їх числі був організований Харківський хіміко-технологічний інститут (ХХТІ). Кафедра технології органічних і фарбувальних речовин була розділена на 3 випускаючі кафедри: кафедра коксобензольного виробництва, кафедра технології органічних барвників і проміжних продуктів і кафедра технології жирів. Кафедра коксобензольного виробництва в 1933 році була перейменована в кафедру технології пірогенних процесів, в 1946 році – в кафедру хімічної технології палива, в 1959 році – в кафедру хімічної технології твердого палива. У 1975 році створено кафедру "Технологія органічних речовин" шляхом злиття кафедр хімічної технології твердого палива та технології органічних барвників і проміжних продуктів.

Кафедра входить до складу Навчально-наукового інституту хімічних технологій та інженерії Національного технічного університету "Харківський політехнічний інститут".

У складі науково-педагогічного колективу кафедри працюють: 2 доктора наук: 1 – фармацевтичних, 1 – біологічних; 7 кандидатів наук: 3 – технічних, 3 – фармацевтичних, 1 – хімічних; 1 співробітник має звання професора, 7 – доцента 1 – старшого наукового співробітника.

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Зараз показуємо 1 - 20 з 378

1,8-Bis(9'-carbazolyl)-3,6-dioxaoctane: Synthesis and Structure
(Ekskluziv Publ., 2015) Shtamburg, V. G.; Shtamburg, V. V.; Zubatyuk, R. I.; Kravchenko, S. V.; Klotz, E. A.; Distanov, V. B.; Uspensky, B. V.
4-формазанонафталіміди – люмінесцентні складові денних флуоресцентних пігментів
(Національний технічний університет "Харківський політехнічний інститут", 2017) Немченко, Н. В.; Дістанов, Віталій Баламірович; Фалалєєва, Тетяна Василівна; Мироненко, Лілія Сергіївна
Analysis of raw materials biotechnology production for cosmetics technology
(Національний технічний університет "Харківський політехнічний інститут", 2021) Delavari, A.; Belinska, Anna
Analysis of the influence of technological parameters of the chlorogenic acid extraction process from sunflower meal on the degree of its extraction
(Технологический Центр, 2020) Labeiko, Marina; Gladkiy, Fedir; Bochkarev, Sergiy; Mazaeva, Viktoria; Litvinenko, Olena; Ovsiannikova, Tetiana; Zhyrnova, Svitlana; Sytnik, Natalia
The object of research is the efficiency of extraction of chlorogenic acid ‑ the natural antioxidant, depending on the conditions of its extraction from sunflower meal. The main problem of this issue is the fact that the extraction degree of the specified phenolic compound is influenced by many factors, such as the degree of grinding of the product, the type of raw material, the method of extraction, the nature of the solvent-extractant, the temperature and duration of the extraction process, the hydromodule in the system "raw – extractant" etc. The impact of each of these parameters requires careful consideration and appropriate research. This will determine the optimal values of the specified parameters of the extraction process and increase the efficiency of extraction of chlorogenic acid. In this work, the raw material for the production of chlorogenic acid is a meal made from sunflower seeds – a cheap second raw material of oil and fat production. Previous studies have found that a high-efficiency extractant of the specified antioxidant is a solution of ethyl alcohol with a concentration of 60 %, and the optimum temperature of the process of extracting chlorogenic acid from sunflower meal is the boiling point of the extractant. As a result of this study, the regularity of the influence on the extraction degree of chlorogenic acid of such technological parameters as the hydromodule in the system "meal – ethyl alcohol solution 60 %" (hereinafter referred to as "meal – extractant") and the duration of the extraction process were studied. Experiments to determine the dependence of the extraction degree of chlorogenic acid on the hydromodule in the system "meal – extractant" and the duration of extraction were carried out in accordance with the plan of the full factor experiment. Mathematical methods using the Microsoft Office Excel 2003 (USA) and Stat Soft Statistica v6.0 (USA) software packages have been applied for experiment planning and data processing. The dependence indicated in the paper is a quadratic function that predicts an increase in chlorogenic acid content during extraction, with an increase in the hydromodule in the "meal‑extractant" system from 1:5 to 1:10 and a decrease in the extraction time from 60 minutes up to 30 minutes. It is established that for the maximum possible increase in the extraction degree of chlorogenic acid from the meal of sunflower seeds, the optimal value of the hydromodule extraction ‑ 1:10, the duration of extraction ‑ 30 minutes. The obtained results allow to increase the extraction degree of chlorogenic acid from sunflower meal from 2.46 % to 5.58 %. This indicates the possibility of increasing the efficiency of extraction of antioxidant more than 2 times.
Determination of the linear dimensions of sunflower seeds of oleic type domestic breeing
(Національний технічний університет "Харкіський політехнічний інститут", 2021) Matvieiev, M.; Papchenko, V.; Matveeva, Т.
Development of the mathematical model of the kinetics of the stationary process of bio-cleaning with substratic inhibition
(Scientific Route OU, 2018) Bakharieva, Ganna; Petrov, Serhii; Falalieieva, Tetiana
A scientifically sound method for calculating the parameters of bio-cleaning should contain as a basic a reliable mathematical description of the stationary process. The results of stationary laboratory experiments are presented in the coordinates “specific rate of destruction V – concentration ρ”. Statistical processing proves the presence of substrate inhibition for both gaseous and soluble and dissolved harmful substances in water. For an analytical description of the dependence of the biooxidation rate on the concentration of contaminants, a phenomenological approach is applied, taking into account in a simple form two obvious phenomena: the contact of a microorganism with a substrate molecule and the inhibitory effect of the medium on it. The numerical values of empirical dependency coefficients for the studied processes are calculated. A differential equation is proposed at the macro level that describes the kinetics of biochemical destruction. The concept of a macrokinetic mathematical model of bioremediation is defined as a system of two functions that quantitatively reflect the dependence of the specific oxidation rate of pollution on its concentration and concentration on time, as well as satisfying the relationship between the relationships of the same parameters in differential form. The dependence of concentration on time is defined both in the form of a numerical integration algorithm and in the form of an approximate formula. The adequacy and universality of the proposed model for the studied processes is proved. The advantage of the proposed model of substrate inhibition kinetics is the simplicity of the structure of the basic formula and the ease of determining empirical coefficients based on this. In addition to numerical integration for determining the time of destruction, an approximate analytical solution is found, which can be adequately used in the concentration range of the experimental study. Further research is aimed at developing methods for calculating non-stationary processes in biochemical purification plants of certain specific types.
Educational innovations and distance education under a pandemic COVID-19
(2020) Tiutiunyk, Larysa Ivanivna; Falalieieva, Tetiana; Motovilnik, Anastasiia Vadimovna; Svitlychnyi, Ya.
EM-mud Balls як економічна та екологічна екобіотехнологія очищення водойм
(Національний технічний університет "Харківський політехнічний інститут", 2021) Манжелій, А. В.; Дикіна, Т. Д.; Бєлінська, Анна Павлівна
How "Street chemistry" and "Street physics" settled at the National Technical University "Kharkiv Polytechnic Institute"
(Copissaurio Repro – Centro Imp. Unip. Lda. Campus de Gualtar, 2018) Minakova, K.; Petrov, Serhii; Radoguz, S.
The importance of methods and methods in nanotechnology, chemical science and industry
(Національний технічний університет "Харківський політехнічний інститут", 2018) Kosmina, Natalya; Krichkovskaya, Lidiya Vasilevna; Petrov, Sergey
Inquiry based science education in National Technical University "Kharkiv Polytechnic Institute" as a way to increase the popularity of natural and thechnical sciences
(Copissaurio Repro – Centro Imp. Unip. Lda. Campus de Gualtar, 2018) Minakova, K.; Petrov, Serhii; Radoguz, S.; Tomashevskyi, R.
The article analyses the problem of reducing the rating of natural sciences in youth. Possible options for solving this issue are considered. Based on the experience of young scientists of the National Technical University "Kharkiv Polytechnic Institute" (NTU "KhPI"), it is indicated on perspective directions of interaction between higher education and secondary school in order to increase the popularity of natural and technical sciences. One of the points of contact can be the foundation of a creative space for children, which will be the focus of STEM education, and promote a positive image of the natural and technical sciences.
Investigation of natural antioxidants for inhibition of peroxidation processes
(The Pharma Innovation, India, 2014) Krichkovskaya, Lidiya Vasilevna; Grycyk, A. R.; Myronenko, L. S.; Zhirnova, S. V.; Mandzii, T. P.; Shumakova, A. S.; Fedorenko, K. Y.
Usage of antioxidants let us struggle against such phenomena as skin withering effectively enough, but free radicals are just one of the mechanisms leading to the aging. Applying of essential oil in complex with microbiological carotene can give the high effect of skin protection against withering at the expense of the decreasing in level of peroxidative oxidation of membranes.
Investigation of the influence of sesame antioxidants on the oxidative stability of provitamin A
(Scientific Route, Estonia, 2019) Ananieva, Valeriya; Belinska, Anna
Microbiological oil solutions of provitamin A (β-carotene) as a dietary supplement are not widely used due to their low oxidation stability. The aim of research is determination of the effect of sesame antioxidants on the oxidative stability of provitamin A in oil solutions. The peroxide number of vegeTable oils is determined by the standard method by the titrimetric method. The value of the period of induction of oil oxidation is determined graphically from the growth curves of peroxide numbers. The content of tocopherols in oils is determined by spectrophotometric method. The content of sesamol and sesamoline in oils is determined by the colorimetric method. The oxidative stability of oils is determined using the accelerated "active oxygen" method. To plan the experiment and process the data, mathematical methods are applied using the software Microsoft Office Excel 2003. The oxidation stability of blended oils (a mixture of sesame, high oleic, sunflower and corn refined oils) and its components is investigated. Blended oil has a lower oxidative stability than sesame oil, but higher than corn and high oleic sunflower. The oxidative stability of the blend is enhanced by the antioxidant content of sesamol and sesamoline. The content of the above antioxidants, as well as the amount of tocopherols, is studied in blended oils. The oxidation stability of the obtained solution of provitamin A in blended oils is investigated. The period of induction of oxidation of blended oils with the addition of 0.2 % β-carotene increases by 1.3 times compared with the period of induction of the original blended oil. Blended long-life oil is recommended to be used to stabilize fat-soluble biologically active compounds.
Justification of concentration of dry extracts from vegetable raw materials in the composition of dental gel
(Національний технічний університет "Харківський політехнічний інститут", 2019) Ananieva, V. V.; Petrov, S. О.
N-аміно- та N-алкілгідрокси похідні 4-морфолінонафтал-іміду – люмінесцентні складові денних флуоресцентних пігментів на різних полімерних основах
(Національний технічний університет "Харківський політехнічний інститут", 2019) Климець, О. М.; Бондарєв, В. В.; Васильєва, В. О.; Дістанов, Віталій Баламірович
Optimization of floccular cleaning and drainage of thin dispersed sludges
(Scientific Route, Estonia, 2020) Shestopalov, Oleksii; Briankin, Oleksandr; Rykusova, Nadegda; Hetta, Oksana S.; Raiko, Valentina; Tseitlin, Musii
The efficiency of solid phase retention and dehydration of finely dispersed products of a coal processing plant and a metallur gical enterprise on the module for cleaning and dewatering sludge is investigated. A technique for selecting the operating parameters of equipment based on the determination of the strength criterion of flocs is proposed. A methodology for technological tests has been developed to control the flocculation process and optimize the flow of flocculant depending on the concentration of the solid phase. Industrial tests on the module for wastewater treatment and sludge dewatering using flocculants proved the effectiveness of the developed methodology. It is shown that the conditions for conducting tests on flocculation should correspond to the operating conditions of the circuit apparatus for cleaning and dewatering sludge. These conditions include sludge performance, sludge flow rate in the cross section of pipes and apparatuses, and the flow time from the flocculator to the centrifuge. During the testing of the Module, the solids retention efficiency of 97–99 % was achieved with the strength criteria of flocs in front of a centrifuge of 2–2.5 mm/s. The conditions for the high efficiency of the apparatus chain are the optimization of the aggregation process itself. It is revealed that for the formation of strong flocs it is necessary to regulate the concentration of the solid phase. For coal sludge, the concentration of the solid phase before the flocculant is fed must be maintained no higher than 50–60 g/l, and for gas treatment sludge – no higher than 20–25 g/l. Correction of the concentration of sludge before the flocculator is possible by diluting it with clarified water to the optimum concentration for aggregation. It is found that the moisture content of the sediment and the efficiency of the retention of the solid phase depend on the strength criterion of the flocs. Therefore, the optimization of the flocculant flow rate is possible by controlling and the residual floccule deposition rate after mechanical action in front of the dewatering equipment. The flocculant flow rate must be adjusted depending on the concentration of the solid phase in the sludge to achieve the desired criterion for the strength of the flocs.
Philosophical-Psychological, Pedagogical-Managerial Aspects of "Qualitative" Formation of Future Specialists of All Levels of Training and Specialties in the Conditions of Technical University
(Shiny World Corporation, Canada, 2022) Ihnatiuk, O. A.; Kostyria, I. V.; Koss, A. M.
The study is devoted to such topical issues in the theory and methodology of education and pedagogy of higher education as the training of future leaders, namely the formation and development of leadership qualities of students in technical universities. On the topic of the study, the authors analyzed the literature of leading scientists in the field of philosophy, psychology and pedagogy, identified features of the formation of leadership in the student environment. The study reveals the seven most important criteria that form the core of the personality of the future specialist leader. The use of these seven criteria of personality development of the future specialist in technical universities requires a combination and adaptation of traditional approaches to education and the latest pedagogical technologies. This is aimed not just at introducing certain forms and methods of work into the educational process, but at creating a specially organized professional environment in which future professionals have opportunities for professional and personal growth through conscious change and transformation of both the environment and themselves. In the process of personal change, the student's historical "I" is as close as possible to his logical "I" and is held by the latter with the help of Onto In-Se. This is how the future specialist acquires leadership qualities, first of all: cognitive, communicative, organizational, moral and volitional and reflexive skills. It is established that through the development of conceptual and creative thinking of the student it is possible to influence the formation of his critical "I" as a necessary attribute of leadership: the ability to listen and hear, understand and act.
Prospectives for Applying of Nanocoatings on Instrumental Tools
(2020) Dubonosov, V. L.; Krichkovskaya, L. V.; Demyanenko, D. V.; Khrypunov, G. S.; Vodoriz, O. S.
The paper is devoted to development of technology and equipment for obtaining of protective reinforcing and heat-shielding thin-film coatings with controlled structure and their usage in production of tools with improved operating characteristics in technological engineering. Recent times much of attention has been paid to creating of wear-resistant hardening coatings and development of multilayer nanosized coatings. By changing the application parameters of such coatings, one can control the composition, particle size, morphology as well as thickness and number of individual layers. Due to this, they can be easily adapted to obtain optimal physical and mechanical properties. The most effective method for coating of cutting tools is ion-plasma vacuum-arc coating deposition (Arc-PVD) which is characterized by high deposition rate and high ionization degree of the vaporized material providing increased adhesion strength of a coating, and this is the main objective of the article.
Research of dry plant concentrates – ingredient of a food health improvement
(Scientific Route, 2016) Ananieva, Valeriya; Krichkovska, Lidiya; Belinska, Anna; Dubonosov, Volodimir; Petrov, Sergiy
It is suggested to perfect technology of production of emulsive foodstuffs, as most consumed by all groups of population of Ukraine, by introduction to compounding of secondary wastes of exit-juice production and vine making as dry concentrates. Such method of enriching of foodstuffs will allow to bring down the deficit of necessary micro- and macronutrients, biologically active substances, and also to bring down indexes on the number of peroxide in the process of storage of low-caloric sauces due to being of natural antioxidants in powdered plant and vegetable material. Experiments were conducted for determination of microand macroelement composition and content of sum of polyphenolic substances samples of powdered plant and vegetable material. Samples with the optimal above-mentioned indexes were revealed and samples for the next stage of researches were chosen. The data plan experiment on the effect of temperature and time storage of powdered vegetable raw materials in the amount polyphenols (% wt) in samples of powdered vegetable raw materials used in the suggested corrections storage term low-calorie sauces based on secondary products of juice and wine manufacturing in recipes and calculations in compounding on productions. It was substantiated the choice of grape skin powder as bioactive addition in the emulsive foodstuffs for health improvment purposes, as a sample that has optimal indexes for micro- and macronutrients composition and maintenance of natural antioxidants of polyphenolic nature.
Research of influence of technological processing parameters of protein-fat base for supply of sportsmen on activity of protease inhibitors
(Technology center, 2017) Bochkarev, Sergiy; Krichkovska, Lidiya; Petrova, Iryna; Petrov, Serhii; Varankina, Oleksandra; Belinska, Anna
The object of research is the biological value of the protein-fat base for athletes, workers of heavy physical labor, military personnel, depending on the conditions of its preliminary processing. A technological audit, the purpose of which was to determine the change in the content of amino acids after enzymatic hydrolysis in samples of the protein-fat base, that had undergone pretreatment by microwave radiation, was conducted. The effectiveness of the protein-fat base pretreatment by microwave radiation was evaluated on the amount of α-amino nitrogen after enzymatic hydrolysis. Based on the analysis of the obtained data, the optimal conditions of the protein-fat base pretreatment were established: 250–350 seconds of microwave treatment time and its hydration to the 12–14 % of moisture content. Such processing will increase the biological value of the protein-fat base, namely, increase the degree of digestion and digestibility of proteins in the gastrointestinal tract.