Кафедра "Органічна хімія, біохімія, лакофарбові матеріали та покриття"

Постійне посилання колекціїhttps://repository.kpi.kharkov.ua/handle/KhPI-Press/7517

Офіційний сайт кафедри http://web.kpi.kharkov.ua/orgchem

Від 2018 року кафедра має назву "Органічна хімія, біохімія, лакофарбові матеріали та покриття". Кафедра створена шляхом об’єднання кафедр "Органічна хімія, біохімія та мікробіологія" та "Технологія полімерних композиційних матеріалів та покриттів" (НАКАЗ № 567 ОД від 12.11.2018 року).

Кафедра "Органічна хімія, біохімія та мікробіологія" (від 2005 року). Кафедра "Лакофарбові матеріали і покриття" була організована у 1944 році в Харківському хіміко–технологічному інституті ім. С.М. Кірова.

Кафедра входить до складу Навчально-наукового інституту хімічних технологій та інженерії Національного технічного університету "Харківський політехнічний інститут".

У складі науково-педагогічного колективу кафедри працюють: 3 доктора та 3 кандидата хімічних наук; 1 співробітник має звання професора, 3 – доцента.

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Зараз показуємо 1 - 20 з 102

1-(N-Alkoxyamino)pyridine Derivatives and others N-Alkoxyhydrazines
(Ekskluziv Publ., 2015) Shtamburg, V. G.; Tsyhankov, A. V.; Shtamburg, V. V.; Klotz, E. A.; Shishkina, S. V.; Zubatyuk, R. I.; Mazepa, A. V.
1-Alkoxyamino-4-dimethylaminopyridinium derivatives as new representatives of O–N–N⁺ geminal systems and their structure
(Elsevier Inc., 2012) Shtamburg, V. G.; Tsygankov, A. V.; Shishkin, O. V.; Zubatyuk, R. I.; Shtamburg, V. V.; Gerasimenko, M. V.; Mazepa, A. V.; Kostyanovsky, R. G.
Acyloxy group exchange in N-acyloxy-N-alkoxyamides
(Elsevier Inc., 2004) Shtamburg, V. G.; Tsyhankov, A. V.; Klots, E. A.; Kostyanovsky, R. G.
Alcoholysis of N-acetoxy-N-alkoxycarbamates. Synthesis of NH-N,N-dialkoxyamines from N,N-dialkoxycarbamates
(Deuton-X Ltd., 2014) Shtamburg, V. G.; Anishchenko, A. A.; Shtamburg, V. V.; Tsygankov, A. V.; Kostyanovsky, R. G.
The alcoholysis of N-acetoxy-N-alkoxycarbamates by methanol or ethanol at 20 – 40 °C yields N,N-dialkoxycarbamates and acetic acid. At the lower temperature the competitive formation of N,N’-bis(alkoxycarbonyl)-N,N’-bis(alkoxy)hydrazines can occur. The alkaline hydrolysis of N,N-dialkoxycarbamates yields NH-N,N-dialkoxyamines.
Application of Doebner-type aminoazole based heterocycle acides in Ugi 4CR
(Ekskluziv Publ., 2018) Murlykina, M. M.; Kolomiets, O. V.; Sakhno, Y. I.; Tsygankov, A. V.; Chebanov, V. A.
Changes in cell membranes of white blood cells treated with a common food additive E407a
(2021) Tkachenko, A. S.; Onishchenko, A.; Posokhov, Ye. O.; Roshal, Alexander; Myasoedov, Valeriy; Nakonechna, Oksana
Changes are detected in the spectra of the fluorescent probe bound to rat WBCs treated with the solutions of E407a of various concentrations in comparison with the corresponding spectra of the probe incubated with the untreated leukocytes. The decrease in polarity and protondonor ability is observed in the lipid membranes of leukocytes in the region, where the probe locates.
Chemistry
(National Technical University "Kharkov Polytechnic Institute", 2018) Bykova, A. S.; Tsygankov, A. V.; Posokhov, Ye. O.
The book presents the material for the study of fundamental discipline "Chemistry" in the undergraduate course. The manual provides concise theoretical material and includes many laboratory works. For the students of specialty "Oil, gas and condensate" and specialty "Management and administration of companies, trade and exchange activities". The book can be used during training of foreign students.
Chiral ureas with two electronegative substituents at 1-N: An unusual case of coexisting pyramidal and almost planar 1-N atoms in the same crystal
(Wiley‐Liss, Inc., 2009) Shishkin, O. V.; Shtamburg, V. G.; Zubatyuk, R. I.; Olefir, D. A.; Tsygankov, A. V.; Prosyanik, A. V.; Mazepa, A. V.; Kostyanovsky, R. G.
XRD studies of structure of N‐acetoxy‐N‐methoxyurea and N,N‐bis(methoxycarbonyl)‐N‐methoxyimide have revealed that in N‐methoxy‐N‐X‐ureas (X = OAc, Cl, OMe, N+C5H5) the additional shortening of N–OMe bond took place, which arising from an nO(Me)‐σ*N–X anomeric orbital interaction. XRD studies of N‐chloro‐N‐ethoxyurea crystal have revealed the presence of two kinds of anomeric nitrogen configuration in the O–N–Cl group in the form of a pyramidal configuration and a planar configuration for same 1‐N nitrogen atom. XRD studies of N‐4‐chlorobenzoyloxy‐N‐ethoxyurea have revealed that the degree of pyramidality of the 1‐N nitrogen in N‐aroyloxy‐N‐alkoxyureas is tuned by orientation of benzoyl group with respect to the N–O bond, which in turn depends of size of N‐alkoxy group.
Controlled doebner-, groebke- and ugi-type multicomponent reactions involving aminoazoles with further in vitro antibacterial and antiviral activity evaluation studies of the reaction products
(Heinrich Heine Universität Düsseldorf, 2018) Murlykina, M. V.; Kornet, M. M.; Van der Eycken, E. V.; Schols, Dominique; Tsygankov, A. V.; Chebanov, V. A.
Diels-Alder adduct isomerization studies using DSC and PMR methods
(Polymate Ltd.-INRC, 2015) Kalkamanova, A. S.; Litvinov, D. A.; Karateiev, A. M.; Koriagin, A. G.
Model Diels-Alder (D-A) adducts of a different isomeric composition were synthesized using furfuryl acetate (FA) and maleimid (MI). The composition of synthesized isomers was analyzed using the proton-magnetic resonance method (PMR). The D-A adduct isomerization process was studied using the differential scanning calorimetry (DSC) method in the nonisothermal mode.
Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction
(BioMed Central, United Kingdom, 2019) Murlykina, M. M.; Kolomiets, O. V.; Kornet, M. M.; Sakhno, Y. I.; Desenko, S. M.; Dyakonenko, V. V.; Shishkina, S. V.; Brazhko, O. A.; Musatov, V. I.; Tsygankov, A. V.; Van der Eycken, E. V.; Chebanov, V. A.
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.
Effects of semi-refined carrageenan (food additive E407a) on cell membranes of leukocytes assessed in vivo and in vitro
(2021) Tkachenko, A. S.; Onishchenko, A.; Roshal, Alexander; Nakonechna, O.; Chumachenko, T.; Posokhov, Ye. O.
No noticeable changes in the physico-chemical properties were observed in the lipid membranes of leukocytes in the region where the probes locate in response to oral intake of semi-refined carrageenan. Incubation of leukocytes with E407a solutions resulted in a decrease in polarity and proton-donor ability of leukocytes in the area of carbonyl groups of phospholipids and in the area of hydrocarbon chains of phospholipids near the polar region of the bilayer.
Experimental Evaluation of Food-Grade Semi-Refined Carrageenan Toxicity
(2021) Pogozhykh, Denys; Posokhov, Ye. O.; Myasoedov, Valeriy; Gubina-Vakulyck, Galina; Chumachenko, Tetyana; Knigavko, Oleksandr; Polikarpova, Hanna; Kalashnyk-Vakulenko, Yuliia; Sharashydze, Ketino; Nakonechna, Oksana; Prokopyuk, Volodymyr; Onishchenko, Anatolii; Tkachenko, Anton
The safety of food additives E407 and E407a has raised concerns in the scientific community. Thus, this study aims to assess the local and systemic toxic effects of the common food additive E407a in rats orally exposed to it for two weeks. Complex evaluations of the effects of semi-refined carrageenan (E407a) on rats upon oral exposure were performed. Local effects of E407a on the intestine were analyzed using routine histological stains and CD68 immunostaining. Furthermore, circulating levels of inflammatory markers were assessed. A fluorescent probe O1O (2-(20-OH-phenyl)-5-phenyl-1,3-oxazole) was used for evaluating the state of leukocyte cell membranes. Cell death modes of leukocytes were analyzed by flow cytometry using Annexin V and 7-aminoactinomycin D staining. Oral administration of the common food additive E407a was found to be associated with altered small and large intestinal morphology, infiltration of the lamina propria in the small intestine with macrophages (CD68+ cells), high systemic levels of inflammation markers, and changes in the lipid order of the phospholipid bilayer in the cell membranes of leukocytes, alongside the activation of their apoptosis. Our findings suggest that oral exposure to E407a through rats results in the development of intestinal inflammation.
Geminal System O-N-O: XRD Studies of Structure of Cyclic N,N-dialkoxyderivatives of Amines and Ureas
(Ekskluziv Publ., 2015) Shtamburg, V. G.; Tsyhankov, A. V.; Klots, E. A.; Kostyanovsky, R. G.
Geminal systems 64.*N-Alkoxy-N-chloroureas and N,N-dialkoxyureas
(Springer and Business Media, Inc., 2015) Shtamburg, V. G.; Kostyanovsky, R. G.; Tsygankov, A. V.; Shtamburg, V. V.; Shishkin, O. V.; Zubatyuk, R. I.; Mazepa, A. V.; Kravchenko, S. V.
Molecular and crystal structures of N-alkoxy-N-chloroureas and N,N-dialkoxyureas were studied together with those of N-alkoxyureas as reference compounds. N-Alkoxy-N-chloroureas were found to have an elongated N—Cl bond and a shortened N—O(Alk) bond due to the nO(Alk)*N—Cl anomeric effect. Alcoholysis of N-alkoxy-N-chloro derivatives of urea, N´-arylureas, and carbamates in the presence of silver trifluoroacetate leads to sterically hindered N,N-dialkoxyureas, N,N-dialkoxy-N´-arylureas, and N,N-dialkoxycarbamates, respectively.
The impact of orally administered gadolinium orthovanadate GdVO₄:Eu³⁺ nanoparticles on the state of phospholipid bilayer of erythrocytes
(2020) Tkachenko, A. S.; Onishchenko, A.; Klochkov, Vladimir; Kavok, Nataliya; Nakonechna, O.; Yefimova, Svetlana; Korniyenko, Yevgen; Ryshchenko, Igor; Posokhov, Ye. O.
No significant changes are detected in the spectra of the fluorescent probes bound to the RBCs from the rats orally exposed to nanoparticles in comparison with the corresponding spectra of the probes bound to the cells from the control group of animals. This indicates that, in case of the rats orally exposed to nanoparticles, no noticeable changes in physico-chemical properties (i.e., in the polarity and the proton-donor ability) are observed in the lipid membranes of RBCs in the region, where the probes locate.
Methanolysis of N-acetoxy-N-n-propyloxy-N’,N’-dimethylurea in different conditions
(Deuton-X Ltd., 2014) Shtamburg, V. G.; Tsygankov, A. V.; Shtamburg, V. V.; Anishchenko, A. A.; Mazepa, A. V.; Kostyanovsky, R. G.
The methanolysis of N-acetoxy-N-n-propyloxy-N’,N’-dimethylurea in the presence of strong acids at room temperatures or in the boiling methanol yields N,N-dimethoxy-N’,N’-dimethylurea as final product. Primarily the nucleophilic substitution acetoxy group at nitrogen on methoxy group arises. At second stage the transesterification of N,N-dialkoxyamino group of formed N-methoxy-N-n-propyloxy-N’,N’-dimethylurea take place.
N,N-Dimethoxy-N-tert-alkylamines: new synthesis methods and the crystal structure of the precursor
(Elsevier Inc., 2006) Shtamburg, V. G.; Tsygankov, A. V.; Klots, E. A.; Fedyanin, I. V.; Lyssenko, K. A.; Kostyanovsky, R. G.
Under the methanolysis of N-methoxy-N-(1-pyridinium)amines salts 1a–c, nucleophilic substitution occurs at the nitrogen atom to form N,N-dimethoxyamines 2a,b; the crystal structure of precursor 1c has been studied.
N-Chloro-N-alkoxyureas: synthesis, structure and properties
(Elsevier Inc., 2006) Shtamburg, V. G.; Shishkin, O. V.; Zubatyuk, R. I.; Kravchenko, S. V.; Tsygankov, A. V.; Mazepa, A. V.; Klots, E. A.; Kostyanovsky, R. G.
The XRD studies of N-chloro-N-alkoxyureas 1, 2 have revealed the high pyramidality of the amide nitrogen in the O–N–Cl group caused by nO–s*N–Cl anomeric effect, the other sequence of this effect is anionic lability of the chlorine atom; nucleophilic substitution at the nitrogen depends on the N'-substitutent nature: chlorine atoms in ureas 1 and 5 are replaced by outer nucleophile whereas, under the same conditions, ureas 2–4 undergo cyclization into 1-alkoxybenzimidazolin-2-ones 10–12.
N-Производные формальдиминов: взаимосвязь между донорно-акцепторными внутримолекулярными взаимодействиями и электронными параметрами атомов
(Украинский государственный химико-технологический университет, 2018) Чертихина, Ю. А.; Куцик-Савченко, Н. В.; Цыганков, Александр Валерьевич; Просяник, А. В.