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Документ The Sulfonation of 3,5,7,3’,4’-Pentahydroxyflavone and Non-Linear-Optical Activity of its Sulfonic Derivatives(Lviv Polytechnic National University, 2019) Mishurov, DmytroSynthesis of sulfoquercetin and studies of its structure and nonlinear properties have been carried out. Using quantum-chemical simulations,13С and HSQC NMR spectrometry, FTIR spectroscopy it was shown that a sulphonic group occurs in C8 location of quercetin. Molecular first hyperpolarizability of the obtained 8-sulfoquercetin was studied. It was shown that 8-sulfoquercetin can be used for creation the new polymer NLO materials on its basis.Документ X-ray diffraction analysis of quercetin and polymers based on its(NGO the Institute for Social Transformation, 2018) Mishurov, Dmytro; Voronkin, Andrii; Roshal, AlexanderSynthesis of glycidyl ethers of quercetin and studies of their structure have been carried out. The X-ray studies of glycidyl ethers of quercetin were performed using by the Debye–Sherrer method. The XRD data are in good correlation with the results of thermophysical studies and analysis by the scanning electron microscopy method, which was carried out earlier.Документ Influence of structure 3,5,7,3',4'–Pentahydroxyflavone-based polymer films on their optical transparency(2017) Mishurov, Dmytro; Voronkin, Andrii; Roshal, Alexander; Bogatyrenko, SergeyOptical properties and morphology of polymer films based on diglycidyl ether of bis-phenol A and on natural compound 3,5,7,30 ,40 epentahydroxyflavone (quercetin) using UVevis spectroscopy, scanning electron microscopy and powder X-ray diffraction methods have been investigated. The influence of ordering degree of the polymers, flexibility of their chains, intensity of intermolecular interaction between the quercetine moieties on the polymers' morphology was discussed. It is shown that all the quercetine-based polymer films are transparent at visible and near infrared regions beginning from 420 to 450 nm. Low optical transparency in the short-wavelength region can be explained the self-absorption of quercetin moieties in the polymer chainsДокумент Study of antioxidant activity of liposomal forms of quercetin and curcumin in ischemic heart disease(Termedia Publishing House, Poland, 2020) Pylypenko, D. M.; Gorbach, T. V.; Krasnopolsky, Yu. M.Quercetin and curcumin are plant polyphenolic antioxidants with proven pharmacological efficacy. Their use is, however, limited due to low bioavailability and oral administration route. The encapsulation of lipophilic compounds in liposomes enables to increase their bioavailability and to create an injectable form. The present study aimed to comparatively investigate the antioxidant activity of a complex liposomal preparation containing two lipophilic antioxidants (quercetin and curcumin) and their monopreparations in liposomal forms. This study was conducted on Wistar line rats with experimental model of ischemic heart disease. Oxidative stress markers such as total antioxidant activity, malondialdehyde, and peroxidized proteins were analyzed in blood serum and cardiac tissue. Ischemic heart disease is accompanied with lipid peroxidation and changes in the activity of the antioxidant system. The obtained results demonstrated the antioxidant activity of monopreparations of curcumin and quercetin and their complex in liposomal forms. Quercetin and curcumin showed different antioxidant activities in terms of oxidative stress markers. The complex of the two antioxidants showed the synergistic effect of their lipophilic compounds in liposomal forms, which led to the normalization of test parameters according to the level of the control sample.Документ A Study of Oxidative Stress Markers when Using the Liposomal Antioxidant Complex(Hellenic Pharmaceutical Society, 2019) Pylypenko, D. M.; Gorbach, T. V.; Katsai, O. G.; Grigoryeva, A. S.; Krasnopolsky, Yu. M.The aim of the study was to create the complex liposomal preparation containing Coenzyme Q10 and Quercetin and learn its antioxidant activity. The liposomes were obtained the lipid film method followed by emulsification with PBS, extrusion and sterilizing filtration. The emulsion was lyophilized with lactose as a cryoprotectant. The ratio of Coenzyme Q10 and Quercetin in complex liposomal composition was 1:1. The particles size and the degree of inclusion were determined. Pharmacological study was carried out on Wistar line rats with experimental ischemic heart disease model. The samples of complex liposomal composition and monocompositions of Coenzyme Q10 and Quercetin were intravenously administered daily for 5 days at a dose of 10 mg/kg. Oxidative stress markers (levels of malondialdehyde, conjugated dienes, sulfhydryl groups, protein peroxidation, enzyme superoxide dismutase catalase and total antioxidant activity) were analyzed in blood serum and cardiac tissue of the rats. The obtained complex composition was characterized by a particle size of up to 220 nm and at least 90.0 % of the included Coenzyme Q10 and Quercetin. A decrease in the level of lipid oxidation products and an increase in the activity of antioxidant system using the complex liposomal preparation containing Coenzyme Q10 and Quercetin compared to its monocompositions in liposomal form were shown.