Tantsura, Y.Tantsura, L.Pylypets, O.Tretyakov, D.2024-06-242024-06-242019CYP2C19 gene polymorphism in children with drugs-resistant epilepsy in Ukraine [Electronic resource] / Tantsura Y., Tantsura L., Pylypets O., Tretyakov D. // Journal of Alzheimers Disease & Parkinsonism : [Parkinsons & Huntington Disease : 5th World Congress and Epilepsy & Treatment : 5th Intern. Conf., August 29-31, 2019. – Electronic text data. – Vienna, 2019. – Vol. 09. – P. 49. – Access mode: https://www.omicsonline.org/conference-proceedings/cyp2c19-gene-polymorphism-in-children-with-drugsresistant.pdf, free (date of the application 24.06.2024.).https://repository.kpi.kharkov.ua/handle/KhPI-Press/78675The frequency with which drugs-resistant epilepsies occur is unchanged and reaches 30%. It is believed that isoenzymes of cytochrome P450 can significantly affect the metabolism, efficacy and safety of AEDs. The purpose of our study was to find out in children with drug-resistant epilepsy the frequency with which polymorphism of isoenzymes of cytochrome P450 - CYP2С19 occurs taking part in biotransformation of most AEDs.endrugs-resistant epilepsiesgene polymorphismallele variant CYP2C19*2metabolismmedicineArticlehttps://orcid.org/0000-0003-4060-3159https://orcid.org/0000-0002-7537-431Xhttps://orcid.org/0000-0002-3471-0145https://orcid.org/0000-0002-1112-5752