Murlykina, M. M.Kolomiets, O. V.Kornet, M. M.Sakhno, Y. I.Desenko, S. M.Dyakonenko, V. V.Shishkina, S. V.Brazhko, O. A.Musatov, V. I.Tsygankov, A. V.Van der Eycken, E. V.Chebanov, V. A.2019-12-102019-12-102019Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction / M. M. Murlykina [et al.] // Beilstein Journal of Organic Chemistry. – 2019. – Vol. 15. – P. 1281-1288.https://repository.kpi.kharkov.ua/handle/KhPI-Press/43240Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.enantibacterial activityDoebner reactionpyrazolo[3,4-b]pyridine carboxylic acidsUgi reactionArticle