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Technical progress on the modern stage of society development is accompanied by the continuous increase of human role in the achievement of high efficiency and quality of work. Complex mechanization of production processes, control systems automation, the usage of computer engineering, and information models of individual and collective usage radically change labor characteristics. A man performs operator functions, his activities continuously become more complicated despite permanent progress of technique and automation of production processes. Modern control system imposes responsibility both on a man, using technique and on that who ensures efficiency and reliability of this usage. Role of human factor in occupational safety is very great. Psychophysiological features of labor process participants are especially important. Psychophysiological basis of safety is based on psychology and physiology of a man. Psychophysiology of occupational safety is based on such sciences as physiology of labor, engineering psychology, ergonomics, etc. Safety psychology considers the application of psychological knowledge for occupational health safety ensurance and is a key point in the structure of actions aimed at human safe activity. Both, internal and external factors influence on the occurrence of such adverse state as stress, fatigue, and decrease in working capacity. The following external factors may be present at production enterprises: microclimat parameters, light, noise, vibration, the other labor environment, social-psychological climate, management style, etc. The following factors may be considered as internal reasons of adverse functional conditions: nervous system type, temperament, professional skills, etc. The aspect of internal factors which have an impact on the appearance of adverse functional conditions is not well studied nowadays. When hiring an employee and during his adaptation it is necessary to take into consideration his psychological features, as they directly impact success and work speed, his condition. It is necessary to take into account an employee's functional conditions during his work performance. The objective of the metodological instructions "Basis of psychophysiological assurance of professional activity reliability and human operator efficiency" is the formation of theoretical knowledge and practical skills which include holistically interconnected physiological and psychological patterns of employee's professional activity, causing efficiency, reliability and occupational health safety, professional health and longevity increase.

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