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  • Ескіз
    Документ
    The impact of orally administered gadolinium orthovanadate GdVO₄:Eu³⁺ nanoparticles on the state of phospholipid bilayer of erythrocytes
    (2020) Tkachenko, A. S.; Onishchenko, A.; Klochkov, Vladimir; Kavok, Nataliya; Nakonechna, O.; Yefimova, Svetlana; Korniyenko, Yevgen; Ryshchenko, Igor; Posokhov, Ye. O.
    No significant changes are detected in the spectra of the fluorescent probes bound to the RBCs from the rats orally exposed to nanoparticles in comparison with the corresponding spectra of the probes bound to the cells from the control group of animals. This indicates that, in case of the rats orally exposed to nanoparticles, no noticeable changes in physico-chemical properties (i.e., in the polarity and the proton-donor ability) are observed in the lipid membranes of RBCs in the region, where the probes locate.
  • Ескіз
    Документ
    Semi-Refined Carrageenan Attenuates Lipopolysaccharide-Induced Reactive Oxygen Species Production in Peripheral Blood Mononuclear Cells and Cell Membrane Alterations in Leukocytes
    (2021) Posokhov, Ye. O.; Onishchenko, A.; Chumachenko, T.; Makieieva, N.; Kalashnyk-Vakulenko, Y.; Polikarpova, H.; Novikova, V.; Prokopyuk, V.; Nakonechna, O.; Chumachenko, D.; Tkachenko, V.; Meniailov, I.; Tkachenko, M.; Tkachenko, A. S.
    Expectedly, incubation with LPS induced ROS generation in PBMCs and decreased the lipid order of cell membranes in leukocytes. E407a alone was found to alter neither ROS production in PBMCs, nor membrane lipid order in leukocytes. Semi-refined carrageenan partially reduced LPS-mediated ROS overproduction in PBMCs and cell membrane alterations in leukocytes.