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Документ Key directions in the organization of health care and prevention actions to reduce mortality from cardiovascular diseases in Ukraine(Graz, Austria, 2020) Mishchenko, M.; Shevchenko, A.; Mishchenko, A.Документ National trends in morbidity and mortality from circulatory system and cerebrovascular diseases and strokes(Wydawnictwo Aluna, 2022) Ognev, Victor A.; Mishchenko, Marina M.; Mishchenko, Alexander N.; Trehub, Pavlo O.The aim: To determine national trends in morbidity and mortality from diseases of the circulatory system, cerebrovascular diseases and strokes. Materials and methods: Data from official sources of statistical information of Ukraine were used and systematic analysis and generalization of the obtained data was performed and trends in morbidity and mortality from diseases of the circulatory system, cerebrovascular diseases and strokes in Ukraine were calculated. Results: Were found tendencies to decrease of national levels of prevalence and primary morbidity in Ukraine for DCS (-16.3 % and -28.0 %), CVD (-22.8 % and 24.1 %) and strokes (-12.2 %) with significant trends (+83.9 %) of increase in primary incidence of strokes in 2010-2017 with fairly high and threatening levels for 2017 (respectively 22199563, 2521601 and 96978 – prevalence and 1725137, 290557 and 96978 – primary incidence). National levels of reduction of deaths from DCS in Ukraine from 440369 (2013) to 389348 (2019) with a trend of -11.6 % and a decrease in mortality due to CVD from 94267 (2013) to 76232 (2019) with a trend -19.1 % were found. Conclusions: The trends to reduce of national prevalence, primary morbidity and mortality rates in Ukraine for DCS, CVD and stroke are fully consistent with other global trends of reduction of these levels among world countries.Документ World strategy on tobacco control and mortality from cardiovascular diseases in Ukraine(SSPG Publish, 2020) Ognev, Victor Andreevich; Mishchenko, Maryna Mykhailovna; Mishchenko, Alexander Nykolaevich; Shevchenko, Alexander SergeevichSince 2003, Ukraine has been participating in the WHO Framework Convention on Tobacco Control and has achieved a slight decrease in the number of smokers according to state medical statistics. The decrease in mortality from cerebral stroke and coronary heart disease over the past 10 years is associated with this fact.Документ Computer modeling of embryonic mortality at crioconservation(Національна академія наук України; Інститут біохімії ім. О. В. Палладіна НАН України, 2016) Gorbunov, L. V.; Cherniavska, Ye. G.The purpose of the research was to determine the regularities of influence of mammalian embryos heterogeneity and effectiveness of cryoconservation steps on their viability by using the developed simulation model. The model is based on analytical expressions that reflect the main causes of embryonic mortality during in vitro and in vivo cultivation, crioconservation and embryo transplantation. Reduction of viability depends on a set of biological factors such as the animal special, donor and recipient state, quality of embryos, and of technological ones such as the efficiency of cryopreservation method, and embryo transplantation. Fulfilled computer experiment showed, that divergence of embryos viability depending on biological parameters variations changes in a range from 0 to 100%, whereas efficiency index of chosen technology has an inaccuracy about 1%. The comparative analysis of alternative technologies of embryos cryopreservation showed the maximum efficiency of stages of use of the cryoprotectant, freezing regime and in vitro and in vivo cultivation of biological object. The application of computer modeling gives an opportunity to reduce the range of embryos viability results, obtained in different experiments is many times, thereby to shorten the time, monetary costs and the slaughter of laboratory animals in obtaining reliable results.