Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction

dc.contributor.authorMurlykina, M. M.en
dc.contributor.authorKolomiets, O. V.en
dc.contributor.authorKornet, M. M.en
dc.contributor.authorSakhno, Y. I.en
dc.contributor.authorDesenko, S. M.en
dc.contributor.authorDyakonenko, V. V.en
dc.contributor.authorShishkina, S. V.en
dc.contributor.authorBrazhko, O. A.en
dc.contributor.authorMusatov, V. I.en
dc.contributor.authorTsygankov, A. V.en
dc.contributor.authorVan der Eycken, E. V.en
dc.contributor.authorChebanov, V. A.en
dc.date.accessioned2019-12-10T09:33:01Z
dc.date.available2019-12-10T09:33:01Z
dc.date.issued2019
dc.description.abstractSubstituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.en
dc.identifier.citationDoebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction / M. M. Murlykina [et al.] // Beilstein Journal of Organic Chemistry. – 2019. – Vol. 15. – P. 1281-1288.en
dc.identifier.urihttps://repository.kpi.kharkov.ua/handle/KhPI-Press/43240
dc.language.isoen
dc.publisherBioMed Central, United Kingdomen
dc.subjectantibacterial activityen
dc.subjectDoebner reactionen
dc.subjectpyrazolo[3,4-b]pyridine carboxylic acidsen
dc.subjectUgi reactionen
dc.titleDoebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reactionen
dc.typeArticleen

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