Changes in energy metabolism of mitochondria in pulmonary diseases and their importance in the pathogenesis of communityacquired pneumonia
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Дата
2021
ORCID
DOI
Науковий ступінь
Рівень дисертації
Шифр та назва спеціальності
Рада захисту
Установа захисту
Науковий керівник
Члени комітету
Видавець
Анотація
The article presents the results of studying the energy metabolism of mitochondria and the antioxidant system in patients with community -acquired pneumonia. It was established that community-acquired pneumonia is an energy-dependent process, which manifests in the form of decreasing the concentration of adenosine triphosphate, against the background of increasing the concentration of adenosine diphosphate and adenosine monophosphate, relative to the indicators of a group of practically healthy humans. It has been proved that changes in the parameters of the lipid peroxidation system serve as markers of the severity of the inflammatory process and the effectiveness of the treatment of community-acquired pneumonia. Decrease of the catalase concentration against the background of increase of the TBA-reactants content and a significant decrease in the antioxidant-prooxidant index (6.5 times) are not only energy -saving mitochondrial mechanisms, but also oxygen -dependent processes. The obtained results expand the possibilities of diagnosing community-acquired pneumonia, which must be considered in establishing the diagnosis. All human studies were conducted in compliance with the rules of the Helsinki Declaration of the World Medical Association "Ethical principles of medical research with human participation as an object of study". Informed consent was obtained from all participants.
Опис
Ключові слова
community-acquired pneumonia, energy processes, mitochondria, antioxidant protection, lipid peroxidation
Бібліографічний опис
Changes in energy metabolism of mitochondria in pulmonary diseases and their importance in the pathogenesis of communityacquired pneumonia / Bereznyakov, V. I. [et al.] // Pharmacologyonline. – 2021. – Vol. 2. – P. 806-811.