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Документ Changes in cell membranes of white blood cells treated with a common food additive E407a(2021) Tkachenko, A. S.; Onishchenko, A.; Posokhov, Ye. O.; Roshal, Alexander; Myasoedov, Valeriy; Nakonechna, OksanaChanges are detected in the spectra of the fluorescent probe bound to rat WBCs treated with the solutions of E407a of various concentrations in comparison with the corresponding spectra of the probe incubated with the untreated leukocytes. The decrease in polarity and protondonor ability is observed in the lipid membranes of leukocytes in the region, where the probe locates.Документ The impact of orally administered gadolinium orthovanadate GdVO₄:Eu³⁺ nanoparticles on the state of phospholipid bilayer of erythrocytes(2020) Tkachenko, A. S.; Onishchenko, A.; Klochkov, Vladimir; Kavok, Nataliya; Nakonechna, O.; Yefimova, Svetlana; Korniyenko, Yevgen; Ryshchenko, Igor; Posokhov, Ye. O.No significant changes are detected in the spectra of the fluorescent probes bound to the RBCs from the rats orally exposed to nanoparticles in comparison with the corresponding spectra of the probes bound to the cells from the control group of animals. This indicates that, in case of the rats orally exposed to nanoparticles, no noticeable changes in physico-chemical properties (i.e., in the polarity and the proton-donor ability) are observed in the lipid membranes of RBCs in the region, where the probes locate.Документ Effects of semi-refined carrageenan (food additive E407a) on cell membranes of leukocytes assessed in vivo and in vitro(2021) Tkachenko, A. S.; Onishchenko, A.; Roshal, Alexander; Nakonechna, O.; Chumachenko, T.; Posokhov, Ye. O.No noticeable changes in the physico-chemical properties were observed in the lipid membranes of leukocytes in the region where the probes locate in response to oral intake of semi-refined carrageenan. Incubation of leukocytes with E407a solutions resulted in a decrease in polarity and proton-donor ability of leukocytes in the area of carbonyl groups of phospholipids and in the area of hydrocarbon chains of phospholipids near the polar region of the bilayer.Документ Semi-Refined Carrageenan Attenuates Lipopolysaccharide-Induced Reactive Oxygen Species Production in Peripheral Blood Mononuclear Cells and Cell Membrane Alterations in Leukocytes(2021) Posokhov, Ye. O.; Onishchenko, A.; Chumachenko, T.; Makieieva, N.; Kalashnyk-Vakulenko, Y.; Polikarpova, H.; Novikova, V.; Prokopyuk, V.; Nakonechna, O.; Chumachenko, D.; Tkachenko, V.; Meniailov, I.; Tkachenko, M.; Tkachenko, A. S.Expectedly, incubation with LPS induced ROS generation in PBMCs and decreased the lipid order of cell membranes in leukocytes. E407a alone was found to alter neither ROS production in PBMCs, nor membrane lipid order in leukocytes. Semi-refined carrageenan partially reduced LPS-mediated ROS overproduction in PBMCs and cell membrane alterations in leukocytes.