(2019) Tantsura, Y.; Tantsura, L.; Pylypets, O.; Tretyakov, D.
The frequency with which drugs-resistant epilepsies occur is unchanged and reaches 30%. It is believed that isoenzymes of cytochrome P450 can significantly affect the metabolism, efficacy and safety of AEDs. The purpose of our study was to find out in children with drug-resistant epilepsy the frequency with which polymorphism of isoenzymes of cytochrome P450 - CYP2С19 occurs taking part in biotransformation of most AEDs.
