CYP2C19 gene polymorphism in children with drugs-resistant epilepsy in Ukraine
Дата
2019
DOI
Науковий ступінь
Рівень дисертації
Шифр та назва спеціальності
Рада захисту
Установа захисту
Науковий керівник
Члени комітету
Назва журналу
Номер ISSN
Назва тому
Видавець
Анотація
The frequency with which drugs-resistant epilepsies occur is unchanged and reaches 30%. It is believed that isoenzymes of cytochrome P450 can significantly affect the metabolism, efficacy and safety of AEDs. The purpose of our study was to find out in children with drug-resistant epilepsy the frequency with which polymorphism of isoenzymes of cytochrome P450 - CYP2С19 occurs taking part in biotransformation of most AEDs.
Опис
Ключові слова
drugs-resistant epilepsies, gene polymorphism, allele variant CYP2C19*2, metabolism, medicine
Бібліографічний опис
CYP2C19 gene polymorphism in children with drugs-resistant epilepsy in Ukraine [Electronic resource] / Tantsura Y., Tantsura L., Pylypets O., Tretyakov D. // Journal of Alzheimers Disease & Parkinsonism : [Parkinsons & Huntington Disease : 5th World Congress and Epilepsy & Treatment : 5th Intern. Conf., August 29-31, 2019. – Electronic text data. – Vienna, 2019. – Vol. 09. – P. 49. – Access mode: https://www.omicsonline.org/conference-proceedings/cyp2c19-gene-polymorphism-in-children-with-drugsresistant.pdf, free (date of the application 24.06.2024.).