CYP2C19 gene polymorphism in children with drugs-resistant epilepsy in Ukraine
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The frequency with which drugs-resistant epilepsies occur is unchanged and reaches 30%. It is believed that isoenzymes of cytochrome P450 can significantly affect the metabolism, efficacy and safety of AEDs. The purpose of our study was to find out in children with drug-resistant epilepsy the frequency with which polymorphism of isoenzymes of cytochrome P450 - CYP2С19 occurs taking part in biotransformation of most AEDs.
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CYP2C19 gene polymorphism in children with drugs-resistant epilepsy in Ukraine [Electronic resource] / Tantsura Y., Tantsura L., Pylypets O., Tretyakov D. // Journal of Alzheimers Disease & Parkinsonism : [Parkinsons & Huntington Disease : 5th World Congress and Epilepsy & Treatment : 5th Intern. Conf., August 29-31, 2019. – Electronic text data. – Vienna, 2019. – Vol. 09. – P. 49. – Access mode: https://www.omicsonline.org/conference-proceedings/cyp2c19-gene-polymorphism-in-children-with-drugsresistant.pdf, free (date of the application 24.06.2024.).