Изменение аутотолерантности у больных, страдающих церебральным арахноидитом на фоне длительного снижения артериального давления

Abstract

Работа посвящена особенностям нарушений в системе нейро-иммунно-эндокринного комплекса у больных с воспалительным поражением центральной нервной системы. Обследовано 62 пациента с церебральным арахноидитом и 45 с физиологической артериальной гипотонией. Выполнено клиническо-неврологическое обследование, определение состояния иммунорезистентности. Персистенция инфекции приводит к нарушению защитных функций организма и структурным повреждениям нервной ткани, что может индуцировать аутоиммунные процессы. Создан лечебно-диагностический алгоритм.The work deals with the features of functional disorders of united regulative system of organism – neuro-im mune-ecdocrine complex – on the background of prolonged persistence of infection in patients with neurological symptom complexes of central nervous system organic injury of inflammatory genesis. Methods. There were examined 107 patients: 62 patients with cerebral arachnoiditis on the background of chronic nidi of infection and 45 patients of the control group with physiological arterial hypotension. There were carried out clinical and neurological examinations, monitoring of the blood pressure, determination of the state of the primary and secondary immunities. Results. Antibodies are synthesized on the background of the prolonged persistence of infection and at the disorder of the protective functions of organism it cause the structural damages of the nervous tissue that by-turn can induce autoimmune processes that are insured by aggressive clones of T-lymphocytes with participation of inflammatory and anti-inflammatory factors. Conclusions. In the complex of treatment it is necessary to use the differentiated therapy taking into account the individual features of heterogeneity of disorders of immunoresistance at prolonged persistence of infection in organism directed to renewal of structural and functional disorders, changes in the primary and secondary immunity link with the use of immunocorrectors, desensitizing preparations, enterosorbents, immunoglobulins, thymus hormones, nucleic acids preparations, plasmapheresis.