Кафедра "Органічна хімія, біохімія, лакофарбові матеріали та покриття"
Постійне посилання колекціїhttps://repository.kpi.kharkov.ua/handle/KhPI-Press/7517
Офіційний сайт кафедри http://web.kpi.kharkov.ua/orgchem
Від 2018 року кафедра має назву "Органічна хімія, біохімія, лакофарбові матеріали та покриття". Кафедра створена шляхом об’єднання кафедр "Органічна хімія, біохімія та мікробіологія" та "Технологія полімерних композиційних матеріалів та покриттів" (НАКАЗ № 567 ОД від 12.11.2018 року).
Кафедра "Органічна хімія, біохімія та мікробіологія" (від 2005 року). Кафедра "Лакофарбові матеріали і покриття" була організована у 1944 році в Харківському хіміко–технологічному інституті ім. С.М. Кірова.
Кафедра входить до складу Навчально-наукового інституту хімічних технологій та інженерії Національного технічного університету "Харківський політехнічний інститут".
У складі науково-педагогічного колективу кафедри працюють: 3 доктора та 3 кандидата хімічних наук; 1 співробітник має звання професора, 3 – доцента.
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Документ Synthesis of ethyl 3,5-dimethyl-4-(aryliminomethyl)-1h-pyrrole-2-carboxylates and their reactions with thioglycolic acid(Ekskluziv Publ., 2018) Mikhedkina, E. I.; Melnik, I. I.; Tsygankov, A. V.; Kozhich, D. T.; Vasyleiko, M. V.Документ Application of Doebner-type aminoazole based heterocycle acides in Ugi 4CR(Ekskluziv Publ., 2018) Murlykina, M. M.; Kolomiets, O. V.; Sakhno, Y. I.; Tsygankov, A. V.; Chebanov, V. A.Документ A study of cell membranes in nasal epithelial cells from patients with chronic rhinosinusitis with nasal polyps by means of a fluorescent probe(2019) Onishchenko, A. I.; Tkachenko, A. S.; Nakonechna, O. A.; Korniyenko, Y. M.; Ryshchenko, I. M.; Tsygankov, A. V.; Posokhov, Ye. O.Aim. To assess the state of membranes in nasal epithelial cells obtained from the patients with chronic rhinosinusitis with nasal polyps (CRSwNP) with the help of the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole. Methods. The state of membrane phospholipid bilayer in suspensions of nasal epithelial cells isolated from ten patients with CRSwNP was evaluated using the fluorescent probe 2-(2ʹ-ОН-phenyl)-5-phenyl-1,3-oxazole that reacts on the physico-chemical properties of its microenvironment. Changes in fluorescence spectra were determined using a Thermo Scientific Lumina fluorescence spectrometer (Thermo Fisher Scientific) 1 hour after the addition of the probe to nasal epithelial cell suspensions. Results. CRSwNP was found to be associated with a higher rate of nasal epithelial cell membrane hydration in the region of phospholipid glycerol moiety, carbonyl groups and aliphatic chains of fatty acids attached to the carbonyl groups. Conclusion. Our findings suggest that CRSwNP is accompanied by the elevated hydration rate of the most polar region, namely polar heads of phospholipids of nasal epithelial cell membranes.Документ 1-Alkoxyamino-4-dimethylaminopyridinium derivatives as new representatives of O–N–N⁺ geminal systems and their structure(Elsevier Inc., 2012) Shtamburg, V. G.; Tsygankov, A. V.; Shishkin, O. V.; Zubatyuk, R. I.; Shtamburg, V. V.; Gerasimenko, M. V.; Mazepa, A. V.; Kostyanovsky, R. G.Документ A study of enterocyte membranes during activation of apoptotic processes in chronic carrageenan-induced gastroenterocolitis(Medical Association of Zenica-Doboj Canton, 2018) Tkachenko, A. S.; Marakushyn, Dmytro; Kalashnyk, Iuliia; Korniyenko, Yevgen; Onishchenko, Anatolii; Gorbach, Tatyana; Nakonechna, Oksana; Posokhov, Ye. O.; Tsygankov, A. V.Aim. To investigate the lipid membranes of rat enterocytes in chronic carrageenan-induced gastroenterocolitis accompanied by the activation of apoptotic processes. Methods. Steady-state fluorescence spectroscopy: a study by fluorescent probes – by ortho-hydroxy derivatives of 2,5-diaryl-1,3-oxazole. Activity of apoptosis signal-regulating kinase 1 and poly (ADP-ribose) polymerase in small intestinal homogenates, blood serum levels of matrix metalloproteinase-2 and caspase-3 and the level of DNA fragmentation in small intestinal homogenates were determined. Results. Biochemical analysis revealed that an activation of apoptotic processes occurred in the intestinal epithelium of rats during chronic carrageenan-induced gastroenterocolitis. The fluorescence probes showed that activation of apoptotic processes in carrageenan-induced gastroenterocolitis was accompanied by changes in polar regions of rat enterocyte membranes, while no changes were revealed in more hydrophobic regions of the membranes. Conclusion. The increase in hydration of membranes was attributed to the activation of the apoptosis of enterocytes. It has been shown that a fluorescent probe (2-(2′-hydroxyphenyl)-5-phenyl-1,3-oxazole) can be used for the detection of apoptosis of enterocytes.Документ Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction(BioMed Central, United Kingdom, 2019) Murlykina, M. M.; Kolomiets, O. V.; Kornet, M. M.; Sakhno, Y. I.; Desenko, S. M.; Dyakonenko, V. V.; Shishkina, S. V.; Brazhko, O. A.; Musatov, V. I.; Tsygankov, A. V.; Van der Eycken, E. V.; Chebanov, V. A.Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.Документ Controlled doebner-, groebke- and ugi-type multicomponent reactions involving aminoazoles with further in vitro antibacterial and antiviral activity evaluation studies of the reaction products(Heinrich Heine Universität Düsseldorf, 2018) Murlykina, M. V.; Kornet, M. M.; Van der Eycken, E. V.; Schols, Dominique; Tsygankov, A. V.; Chebanov, V. A.Документ Synthesis and structure of N-alkoxyhydrazines and N-alkoxy-N',N',N'-trialkylhydrazinium salts(Elsevier Inc., 2013) Shtamburg, V. G.; Shishkin, O. V.; Zubatyuk, R. I.; Shtamburg, V. V.; Tsygankov, A. V.; Mazepa, A. V.; Kadorkina, G. K.; Kostyanovsky, R. G.New types of 1,1,1-trialkyl-2-alkoxyhydrazinium chlorides and N-alkoxyhydrazines were obtained by reactions of N-chloro-N-alkoxyureas with trimethylamine or 1,4-diaza[2.2.2]bicyclooctane and by reactions of methyl N chloro-N-methoxycarbamate with potassium salt of N-acetylbenzenesulfonylamide. The XRD studies of N,N' bis(methoxycarbonyl)-N,N'-dimethoxyhydrazine, N'-methoxy-N'‑methoxycarbonyl-N-acetylbenzenesulfonylhydrazide and 1,1,1-trimethyl-2-methoxyhydrazinium perchlorate revealed the pyramidal configuration of the central nitrogen atoms in O–N–N geminal system, unusual elongation of N–N+ bond and shortening of N–OMe bond in 1,1,1-trimethyl-2-methoxyhydrazinium perchlorate.Документ The properties and structure of N-chloro-N-methoxy-4-nitrobenzamide(Elsevier Inc., 2012) Shtamburg, V. G.; Tsygankov, A. V.; Shishkin, O. V.; Zubatyuk, R. I.; Uspensky, B. V.; Shtamburg, V. V.; Mazepa, A. V.; Kostyanovsky, R. G.The XRD study of N-chloro-N-methoxy-4-nitrobenzamide revealed the high pyramidality degree of its amide nitrogen atom in O–N–Cl moiety. N-Chloro-N-methoxy-4-nitrobenzamide reacts with AcONa in MeCN selectively forming N-acetoxy-N-methoxy-4-nitrobenzamide, whereas its methanolysis in the presence of AcONa yields N,N' bis(4-nitrobenzoyl)-N,N'-dimethoxyhydrazine.Документ New approach to N,N-dialkoxy-N'-arylureas and N,N-dialkoxycarbamates(Elsevier Inc., 2011) Shtamburg, V. G.; Tsygankov, A. V.; Gerasimenko, M. V.; Shishkin, O. V.; Zubatyuk, R. I.; Mazepa, A. V.; Kostyanovsky, R. G.Methanolysis of N-chloro-N-alkoxy-N'-arylureas in the presence of silver trifluoroacetate gives the corresponding N,N-dialkoxy-N'‑arylureas, whereas N-chloro-N-alkoxycarbamates react with alcohols in the presence of silver trifluoroacetate to afford N,N-dialkoxycarbamates.