Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction
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Дата
2019
ORCID
DOI
Науковий ступінь
Рівень дисертації
Шифр та назва спеціальності
Рада захисту
Установа захисту
Науковий керівник
Члени комітету
Видавець
BioMed Central, United Kingdom
Анотація
Substituted 1H-pyrazolo[3,4-b]pyridine-4- and 1H-pyrazolo[3,4-b]pyridine-6-carboxamides have been synthetized through a Doebner–Ugi multicomponent reaction sequence in a convergent and versatile manner using diversity generation strategies: combination of two multicomponent reactions and conditions-based divergence strategy. The target products contain as pharmacophores pyrazolopyridine and peptidomimetic moieties with four points of diversity introduced from readily available starting materials including scaffold diversity. A small focused compound library of 23 Ugi products was created and screened for antibacterial activity.
Опис
Ключові слова
antibacterial activity, Doebner reaction, pyrazolo[3,4-b]pyridine carboxylic acids, Ugi reaction
Бібліографічний опис
Doebner-type pyrazolopyridine carboxylic acids in an Ugi four-component reaction / M. M. Murlykina [et al.] // Beilstein Journal of Organic Chemistry. – 2019. – Vol. 15. – P. 1281-1288.