Кафедра "Органічний синтез та фармацевтичні технології"

Постійне посилання колекціїhttps://repository.kpi.kharkov.ua/handle/KhPI-Press/7484

Офіційний сайт кафедри http://web.kpi.kharkov.ua/nanochem

Від січня 2022 року кафедра має назву "Органічний синтез та фармацевтичні технології", попередня назва – "Органічний синтез та нанотехнології" (НАКАЗ 31 ОД від 21.01.2022 року).

Найбільш істотну реорганізацію зазнала кафедра в 1929-1950 роках, коли відбувся поділ на ряд галузевих інститутів, і в їх числі був організований Харківський хіміко-технологічний інститут (ХХТІ). Кафедра технології органічних і фарбувальних речовин була розділена на 3 випускаючі кафедри: кафедра коксобензольного виробництва, кафедра технології органічних барвників і проміжних продуктів і кафедра технології жирів. Кафедра коксобензольного виробництва в 1933 році була перейменована в кафедру технології пірогенних процесів, в 1946 році – в кафедру хімічної технології палива, в 1959 році – в кафедру хімічної технології твердого палива. У 1975 році створено кафедру "Технологія органічних речовин" шляхом злиття кафедр хімічної технології твердого палива та технології органічних барвників і проміжних продуктів.

Кафедра входить до складу Навчально-наукового інституту хімічних технологій та інженерії Національного технічного університету "Харківський політехнічний інститут".

У складі науково-педагогічного колективу кафедри працюють: 2 доктора наук: 1 – фармацевтичних, 1 – біологічних; 7 кандидатів наук: 3 – технічних, 3 – фармацевтичних, 1 – хімічних; 1 співробітник має звання професора, 7 – доцента 1 – старшого наукового співробітника.

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Analysis of raw materials biotechnology production for cosmetics technology
(Національний технічний університет "Харківський політехнічний інститут", 2021) Delavari, A.; Belinska, Anna
Research of quality indicators of proteinfat mixture from flax and sesame seeds for nutrition of athletes
(Scientific Route, Estonia, 2019) Bochkarev, Sergiy; Belinska, Anna; Varankina, Oleksandra; Ananieva, Valeriya; Petik, Igor; Koshyl, Andrii; Yevstifieieva, Olha; Rudnieva, Kateryna
The aim of the research is to determine the microbiological stability of a protein-fat mixture of flax and sesame seeds that allows to correct its storage life. A protein-fat mixture has a high content of irreplaceable amino acids ВСАА and polyunsaturated fatty acids of ω-3group, so it may be positioned as a component of nutrition for athletes. Flax and sesame seeds, cultivated in Ukraine, were used as research materials. The product was created, based on comminuted flax and sesame seeds in ratio 1:1. There were determined organoleptic (outlook, taste, smell, color) and physical-chemical (mass share of moisture, ash, protein, fat, acidic, peroxide, anisidine number) parameters of the product. There was determined the microbiological stability of the protein-fat mixture of the increased food value for athletes nutrition after 6 months. It has been proved, that as opposite to the control sample, the protein-fat mixture of the developed composition manifests its microbiological stability by the following parameters: content of mesophilic aerobic and facultative anaerobic microorganisms, molds, yeast, bacteria of the colon bacillus group and pathogenic microorganisms. The control sample that is comminuted flax seeds doesn’t manifest at the end of the storage term any correspondence of microbiological parameters by the content of mesophilic aerobic and facultative anaerobic microorganisms, molds, and bacteria of the colon bacillus group. This regularity is explained by the presence of lignans, sesamol and sesamoline, with preservative properties in the developed product. The obtained data may be used for reasoning recipes of products, based on the protein-fat mixture and correction of the food supplements ratio in them.
Investigation of the influence of sesame antioxidants on the oxidative stability of provitamin A
(Scientific Route, Estonia, 2019) Ananieva, Valeriya; Belinska, Anna
Microbiological oil solutions of provitamin A (β-carotene) as a dietary supplement are not widely used due to their low oxidation stability. The aim of research is determination of the effect of sesame antioxidants on the oxidative stability of provitamin A in oil solutions. The peroxide number of vegeTable oils is determined by the standard method by the titrimetric method. The value of the period of induction of oil oxidation is determined graphically from the growth curves of peroxide numbers. The content of tocopherols in oils is determined by spectrophotometric method. The content of sesamol and sesamoline in oils is determined by the colorimetric method. The oxidative stability of oils is determined using the accelerated "active oxygen" method. To plan the experiment and process the data, mathematical methods are applied using the software Microsoft Office Excel 2003. The oxidation stability of blended oils (a mixture of sesame, high oleic, sunflower and corn refined oils) and its components is investigated. Blended oil has a lower oxidative stability than sesame oil, but higher than corn and high oleic sunflower. The oxidative stability of the blend is enhanced by the antioxidant content of sesamol and sesamoline. The content of the above antioxidants, as well as the amount of tocopherols, is studied in blended oils. The oxidation stability of the obtained solution of provitamin A in blended oils is investigated. The period of induction of oxidation of blended oils with the addition of 0.2 % β-carotene increases by 1.3 times compared with the period of induction of the original blended oil. Blended long-life oil is recommended to be used to stabilize fat-soluble biologically active compounds.
Research of influence of technological processing parameters of protein-fat base for supply of sportsmen on activity of protease inhibitors
(Technology center, 2017) Bochkarev, Sergiy; Krichkovska, Lidiya; Petrova, Iryna; Petrov, Serhii; Varankina, Oleksandra; Belinska, Anna
The object of research is the biological value of the protein-fat base for athletes, workers of heavy physical labor, military personnel, depending on the conditions of its preliminary processing. A technological audit, the purpose of which was to determine the change in the content of amino acids after enzymatic hydrolysis in samples of the protein-fat base, that had undergone pretreatment by microwave radiation, was conducted. The effectiveness of the protein-fat base pretreatment by microwave radiation was evaluated on the amount of α-amino nitrogen after enzymatic hydrolysis. Based on the analysis of the obtained data, the optimal conditions of the protein-fat base pretreatment were established: 250–350 seconds of microwave treatment time and its hydration to the 12–14 % of moisture content. Such processing will increase the biological value of the protein-fat base, namely, increase the degree of digestion and digestibility of proteins in the gastrointestinal tract.
Research of the oilseeds ratio on the oxidative stability of the protein-fat base for sportsmen
(Technology center, 2017) Bochkarev, Sergiy; Matveeva, Tatiana; Krichkovska, Lidiya; Petrova, Iryna; Petrov, Serhii; Belinska, Anna
The problem of improving physical performance and accelerating the course of recovery processes after physical exertion is one of the most pressing problems of medicine and sports. Nutrition is one of the main controlled factors that ensure the normal development of the body, health and quality of life. Nowadays the assortment of products is mainly expanded due to introduction of new technologies, application of new chemical compounds, development of genetic engineering. At the same time, daily food cannot provide the athlete's body with nutrients in the required amount. And, as a result, in recent years, to speed up regeneration, actively replenish spent plastic and energy resources, very often in sports use biologically active additives. One of the promising areas for improving the efficiency of athletes is the introduction in food rations qualitatively new food products that meet the needs of their body and at the same time have a long shelf life. The aim of this study is to evaluate the oxidation processes of the protein-fat basis, which can be used to organize the rational nutrition of athletes. The oxidative stability of the crushed sunflower seeds, sesame seeds, flax and mixtures was studied at various component ratios. It has been established that sesame seeds are the least susceptible to oxidation, and most of all – flax seeds. Among mixtures of seeds, the most prone to oxidation are mixtures that contain flax seeds and sunflower seeds. When adding sesame seeds to the mixture, the oxidative stability increases sharply. The optimal content (% by weight) of oil seeds in a protein-fat basis was calculated using the method of mathematical experiment planning in the software package "Statistica". The period of induction of oxidation of this mixture is 1.3–1.4 times higher than the induction period of sunflower seeds and 2.7–3.0 times higher than the induction period of flax seed. The use of such basis in food technologies, in particular the confectionery industry, opens up wide opportunities for expanding the range of specialized products for athletes.
Research of dry plant concentrates – ingredient of a food health improvement
(Scientific Route, 2016) Ananieva, Valeriya; Krichkovska, Lidiya; Belinska, Anna; Dubonosov, Volodimir; Petrov, Sergiy
It is suggested to perfect technology of production of emulsive foodstuffs, as most consumed by all groups of population of Ukraine, by introduction to compounding of secondary wastes of exit-juice production and vine making as dry concentrates. Such method of enriching of foodstuffs will allow to bring down the deficit of necessary micro- and macronutrients, biologically active substances, and also to bring down indexes on the number of peroxide in the process of storage of low-caloric sauces due to being of natural antioxidants in powdered plant and vegetable material. Experiments were conducted for determination of microand macroelement composition and content of sum of polyphenolic substances samples of powdered plant and vegetable material. Samples with the optimal above-mentioned indexes were revealed and samples for the next stage of researches were chosen. The data plan experiment on the effect of temperature and time storage of powdered vegetable raw materials in the amount polyphenols (% wt) in samples of powdered vegetable raw materials used in the suggested corrections storage term low-calorie sauces based on secondary products of juice and wine manufacturing in recipes and calculations in compounding on productions. It was substantiated the choice of grape skin powder as bioactive addition in the emulsive foodstuffs for health improvment purposes, as a sample that has optimal indexes for micro- and macronutrients composition and maintenance of natural antioxidants of polyphenolic nature.