Кафедра "Органічний синтез та фармацевтичні технології"

Постійне посилання колекціїhttps://repository.kpi.kharkov.ua/handle/KhPI-Press/7484

Офіційний сайт кафедри http://web.kpi.kharkov.ua/nanochem

Від січня 2022 року кафедра має назву "Органічний синтез та фармацевтичні технології", попередня назва – "Органічний синтез та нанотехнології" (НАКАЗ 31 ОД від 21.01.2022 року).

Найбільш істотну реорганізацію зазнала кафедра в 1929-1950 роках, коли відбувся поділ на ряд галузевих інститутів, і в їх числі був організований Харківський хіміко-технологічний інститут (ХХТІ). Кафедра технології органічних і фарбувальних речовин була розділена на 3 випускаючі кафедри: кафедра коксобензольного виробництва, кафедра технології органічних барвників і проміжних продуктів і кафедра технології жирів. Кафедра коксобензольного виробництва в 1933 році була перейменована в кафедру технології пірогенних процесів, в 1946 році – в кафедру хімічної технології палива, в 1959 році – в кафедру хімічної технології твердого палива. У 1975 році створено кафедру "Технологія органічних речовин" шляхом злиття кафедр хімічної технології твердого палива та технології органічних барвників і проміжних продуктів.

Кафедра входить до складу Навчально-наукового інституту хімічних технологій та інженерії Національного технічного університету "Харківський політехнічний інститут".

У складі науково-педагогічного колективу кафедри працюють: 2 доктора наук: 1 – фармацевтичних, 1 – біологічних; 7 кандидатів наук: 3 – технічних, 3 – фармацевтичних, 1 – хімічних; 1 співробітник має звання професора, 7 – доцента 1 – старшого наукового співробітника.

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Research of influence of technological processing parameters of protein-fat base for supply of sportsmen on activity of protease inhibitors
(Technology center, 2017) Bochkarev, Sergiy; Krichkovska, Lidiya; Petrova, Iryna; Petrov, Serhii; Varankina, Oleksandra; Belinska, Anna
The object of research is the biological value of the protein-fat base for athletes, workers of heavy physical labor, military personnel, depending on the conditions of its preliminary processing. A technological audit, the purpose of which was to determine the change in the content of amino acids after enzymatic hydrolysis in samples of the protein-fat base, that had undergone pretreatment by microwave radiation, was conducted. The effectiveness of the protein-fat base pretreatment by microwave radiation was evaluated on the amount of α-amino nitrogen after enzymatic hydrolysis. Based on the analysis of the obtained data, the optimal conditions of the protein-fat base pretreatment were established: 250–350 seconds of microwave treatment time and its hydration to the 12–14 % of moisture content. Such processing will increase the biological value of the protein-fat base, namely, increase the degree of digestion and digestibility of proteins in the gastrointestinal tract.
Research of the oilseeds ratio on the oxidative stability of the protein-fat base for sportsmen
(Technology center, 2017) Bochkarev, Sergiy; Matveeva, Tatiana; Krichkovska, Lidiya; Petrova, Iryna; Petrov, Serhii; Belinska, Anna
The problem of improving physical performance and accelerating the course of recovery processes after physical exertion is one of the most pressing problems of medicine and sports. Nutrition is one of the main controlled factors that ensure the normal development of the body, health and quality of life. Nowadays the assortment of products is mainly expanded due to introduction of new technologies, application of new chemical compounds, development of genetic engineering. At the same time, daily food cannot provide the athlete's body with nutrients in the required amount. And, as a result, in recent years, to speed up regeneration, actively replenish spent plastic and energy resources, very often in sports use biologically active additives. One of the promising areas for improving the efficiency of athletes is the introduction in food rations qualitatively new food products that meet the needs of their body and at the same time have a long shelf life. The aim of this study is to evaluate the oxidation processes of the protein-fat basis, which can be used to organize the rational nutrition of athletes. The oxidative stability of the crushed sunflower seeds, sesame seeds, flax and mixtures was studied at various component ratios. It has been established that sesame seeds are the least susceptible to oxidation, and most of all – flax seeds. Among mixtures of seeds, the most prone to oxidation are mixtures that contain flax seeds and sunflower seeds. When adding sesame seeds to the mixture, the oxidative stability increases sharply. The optimal content (% by weight) of oil seeds in a protein-fat basis was calculated using the method of mathematical experiment planning in the software package "Statistica". The period of induction of oxidation of this mixture is 1.3–1.4 times higher than the induction period of sunflower seeds and 2.7–3.0 times higher than the induction period of flax seed. The use of such basis in food technologies, in particular the confectionery industry, opens up wide opportunities for expanding the range of specialized products for athletes.
Inquiry based science education in National Technical University "Kharkiv Polytechnic Institute" as a way to increase the popularity of natural and thechnical sciences
(Copissaurio Repro – Centro Imp. Unip. Lda. Campus de Gualtar, 2018) Minakova, K.; Petrov, Serhii; Radoguz, S.; Tomashevskyi, R.
The article analyses the problem of reducing the rating of natural sciences in youth. Possible options for solving this issue are considered. Based on the experience of young scientists of the National Technical University "Kharkiv Polytechnic Institute" (NTU "KhPI"), it is indicated on perspective directions of interaction between higher education and secondary school in order to increase the popularity of natural and technical sciences. One of the points of contact can be the foundation of a creative space for children, which will be the focus of STEM education, and promote a positive image of the natural and technical sciences.
How "Street chemistry" and "Street physics" settled at the National Technical University "Kharkiv Polytechnic Institute"
(Copissaurio Repro – Centro Imp. Unip. Lda. Campus de Gualtar, 2018) Minakova, K.; Petrov, Serhii; Radoguz, S.
Development of the mathematical model of the kinetics of the stationary process of bio-cleaning with substratic inhibition
(Scientific Route OU, 2018) Bakharieva, Ganna; Petrov, Serhii; Falalieieva, Tetiana
A scientifically sound method for calculating the parameters of bio-cleaning should contain as a basic a reliable mathematical description of the stationary process. The results of stationary laboratory experiments are presented in the coordinates “specific rate of destruction V – concentration ρ”. Statistical processing proves the presence of substrate inhibition for both gaseous and soluble and dissolved harmful substances in water. For an analytical description of the dependence of the biooxidation rate on the concentration of contaminants, a phenomenological approach is applied, taking into account in a simple form two obvious phenomena: the contact of a microorganism with a substrate molecule and the inhibitory effect of the medium on it. The numerical values of empirical dependency coefficients for the studied processes are calculated. A differential equation is proposed at the macro level that describes the kinetics of biochemical destruction. The concept of a macrokinetic mathematical model of bioremediation is defined as a system of two functions that quantitatively reflect the dependence of the specific oxidation rate of pollution on its concentration and concentration on time, as well as satisfying the relationship between the relationships of the same parameters in differential form. The dependence of concentration on time is defined both in the form of a numerical integration algorithm and in the form of an approximate formula. The adequacy and universality of the proposed model for the studied processes is proved. The advantage of the proposed model of substrate inhibition kinetics is the simplicity of the structure of the basic formula and the ease of determining empirical coefficients based on this. In addition to numerical integration for determining the time of destruction, an approximate analytical solution is found, which can be adequately used in the concentration range of the experimental study. Further research is aimed at developing methods for calculating non-stationary processes in biochemical purification plants of certain specific types.
Studying the physicochemical regularities in the color- and phase formation processes of clinker ceramic materials
(Technology center, 2018) Fedorenko, Olena; Prysiazhna, Larysa; Petrov, Serhii; Chyrkina, Maryna; Borysenko, Oksana
The paper reports results of a comprehensive study, aimed at developing formulation-technological parameters for obtaining volumetrically dyed clinker ceramic materials with a wide range of colors. A possibility has been proven to obtain a ceramic clinker when using the polymineral clay raw materials at a temperature of 1,100 °C. The expediency has been shown to replace expensive ceramic pigments in the composition of masses with anthropogenic materials containing the oxides of metals with variable valency: wastes from alkaline earth syenite extraction, pegmatite enrichment, and production of ferrotitanium alloys. This shows possibilities for reducing the production cost of clinker ceramic articles. The influence of the formulation of raw materials compositions on the processes of color- and phase-formation of ceramic clinker has been investigated, depending on the character of furnace atmosphere.